ChondroFiller®liquidSupplied in the UK by Actomed

For patients and carers

A collagen implant used to fill a damaged patch of cartilage during keyhole surgery.

ChondroFiller® liquid is a collagen-based implant made from purified animal collagen, as described in the published literature. It is placed into a prepared cartilage defect during keyhole surgery, where it sets into a gel within minutes. It is supplied in the UK by Actomed.

Find a clinicWhat it is
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Healthcare professional? Product information, technique, evidence, training and UK ordering are in the professional section.

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In short

  • It is made from purified animal collagen, as described in the published literature.1
  • It is placed into a prepared cartilage defect during keyhole (arthroscopic) surgery, where it sets into a gel within minutes.3
  • Whether it is an option for you is decided by the surgeon who examines you and looks at your scans.
  • It is manufactured by Meidrix Biomedicals GmbH, Esslingen, Germany, and supplied to UK clinics by Actomed.
ChondroFiller liquid 1.0 ml and 2.3 ml packs with a pre-filled dual-chamber syringe resting on them
The dual-chamber syringe and mixing adapter, illustrative

Who it may be for

Whether ChondroFiller is worth considering for you.

A surgeon and a patient looking at a knee MRI on a monitor in a consultation room
Whether it is an option is decided in consultation, with your scans, illustrative

ChondroFiller® liquid is used to fill cartilage damage in joints such as the knee, hip, shoulder and ankle, following the manufacturer’s intended use.8

Whether it is an option for your joint is a decision for the surgeon who examines you and looks at your scans. The published studies cover the knee, hip and ankle, with follow-up of one to five years.2,4,7

Is it for me?

What happens

From consultation to keyhole surgery and follow-up.

An arthroscopic procedure in an operating theatre

  1. Step 01

    Consultation and imaging

    A surgeon assesses your joint, your history and your scans, and discusses whether ChondroFiller is worth considering for you.

  2. Step 02

    Decision with the surgeon

    You and your surgeon decide together whether to go ahead. Clinics set their own fees; ask the clinic.

  3. Step 03

    Keyhole procedure

    During keyhole (arthroscopic) surgery, the surgeon prepares the cartilage defect and places ChondroFiller into it, where it forms a gel within minutes.

  4. Step 04

    Recovery and follow-up

    Your surgeon will talk you through aftercare and arrange follow-up.

What the studies found

The published evidence, in plain English.

The published research on ChondroFiller liquid consists of small studies, mostly single-arm, followed for between one and five years, with two series extending to five years or more. Results vary between studies and no large UK trial has been published. Ask a clinic what the evidence means for your own joint.4,5,6,7,2

The manufacturer states: 'In rare cases, hypersensitivity reactions to collagen such as allergic or inflammatory reactions can occur.' No adverse events were reported in the published multicentre trial of 23 randomised patients, 13 of whom received ChondroFiller. If you notice anything you are concerned about after treatment, contact the clinic that treated you.8,2

Read the evidence(written for professionals)

Your clinician decides

Only a surgeon who has examined you and seen your scans can say whether ChondroFiller is an option. Find a clinic.

Where to start

Clinics that stock ChondroFiller.

Actomed supplies ChondroFiller and trains clinic teams to use it. Actomed does not assess or treat patients, does not recommend one clinic over another, and being seen by a clinic is not a decision to go ahead with treatment.

Harley Street, London

London Cartilage Clinic

A private cartilage and joint-preservation clinic on Harley Street, offering surgical assessment and treatment for cartilage damage in the knee, hip and ankle.

Shares ownership with Actomed, the UK supplier

Lincolnshire

MSK Doctors

A multi-specialty musculoskeletal clinic group offering orthopaedic assessment and surgical treatment for joint and cartilage conditions.

Shares ownership with Actomed, the UK supplier

Lincolnshire

Lincolnshire Knee Clinic

A knee-focused orthopaedic clinic offering assessment and surgical treatment for knee cartilage and joint conditions.

Shares ownership with Actomed, the UK supplier

Find a clinic

Studies mentioned on this page

  1. 1.Perez-Carro L, Mendoza Alejo PR, Gutierrez Castanedo G, Menendez Solana G, Fernandez Divar JA, Galindo Rubin P, Alfonso Fernandez A. Hip Chondral Defects: Arthroscopic Treatment With the Needle and Curette Technique and ChondroFiller. Arthroscopy Techniques, 10(7):e1669-e1675, 2021. View DOI
  2. 2.Schneider U. Controlled, randomized multicenter study to compare compatibility and safety of ChondroFiller liquid (cell free 2-component collagen gel) with microfracturing of patients with focal cartilage defects of the knee joint. Video Journal of Orthopedics Surgery, 1:1-8, 2016. View DOI
  3. 3.Meidrix Biomedicals GmbH. ChondroFiller® liquid overview brochure. Manufacturer publication, 2024. View source
  4. 4.Mazek J, Gnatowski M, Salas AP, O’Donnell JM, Domżalski M, Radzimowski J. Arthroscopic utilization of ChondroFiller gel for the treatment of hip articular cartilage defects: a cohort study with 12- to 60-month follow-up. Journal of Hip Preservation Surgery, 8(1):22, 2021. View DOI
  5. 5.Simeonov E. Implantation of ChondroFiller Liquid as a Scaffold Material for the Treatment of Chondral Lesions of the Knee Joint. Journal of IMAB, 30(4):5936-5941, 2024. View DOI
  6. 6.De Lucas Villarrubia JC, Méndez Alonso MÁ, Sanz Pérez MI, Trell Lesmes F, Panadero Tapia A. Acellular Matrix-Induced Chondrogenesis Technique Improves the Results of Chondral Lesions Associated with Femoroacetabular Impingement. Arthroscopy, 2021. View DOI
  7. 7.Gatti SD, Vermorel PH, Vega J, Batista J, Guelfi M. Clinical and functional outcomes of arthroscopic autologous collagen-induced chondrogenesis (ACIC) for osteochondral lesions of the talus: A retrospective case series. Journal of Experimental Orthopaedics, 13(1):e70642, 2026. View DOI
  8. 8.Meidrix Biomedicals GmbH. ChondroFiller® liquid patient education leaflet. Manufacturer publication, 2022. View source

Find a clinic that offers ChondroFiller

Actomed supplies ChondroFiller and trains clinic teams to use it. Actomed does not assess or treat patients, does not recommend one clinic over another, and being seen by a clinic is not a decision to go ahead with treatment.

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